{"id":264351,"date":"2026-06-04T15:52:00","date_gmt":"2026-06-04T19:52:00","guid":{"rendered":"https:\/\/news-you-need.com\/index.php\/2026\/06\/04\/novel-technology-maps-single-cell-dna-protein-interactions\/"},"modified":"2026-06-04T16:40:08","modified_gmt":"2026-06-04T20:40:08","slug":"novel-technology-maps-single-cell-dna-protein-interactions","status":"publish","type":"post","link":"https:\/\/news-you-need.com\/index.php\/2026\/06\/04\/novel-technology-maps-single-cell-dna-protein-interactions\/","title":{"rendered":"Novel technology maps single-cell DNA-protein interactions"},"content":{"rendered":"

Novel technology maps single-cell DNA-protein interactions<\/a><\/p>\n

https:\/\/www.news-medical.net\/news\/20260604\/Novel-technology-maps-single-cell-DNA-protein-interactions.aspx<\/a><\/p>\n

Publish Date: 2026-06-04 15:52:00<\/a><\/p>\n

Source Domain: www.news-medical.net<\/a><\/p>\n

<\/span><\/p>\n

A new technology allows scientists to map, in single cells, the DNA binding sites of transcription factors and other regulatory proteins that control gene activity, according to a study led by investigators at Weill Cornell Medicine and the New York Genome Center. With key advantages over methods currently in use, the technology is expected to be a powerful addition to biologists’ toolkit for studying cells in health and disease.<\/p>\n

“D&D-seq,” as the new method is called, uses antibodies to bring a DNA-editing enzyme close to a target protein, allowing researchers to record where that protein interacts with DNA. The study describing the technique, published June 4 in Cell, showed that it surmounts key technical drawbacks of current methods for mapping protein-DNA interactions, and is the first of its kind that can be easily incorporated into high-throughput, single-cell “multi-omics” workflows.<\/p>\n

“A lot of research has been held back because we didn’t have the right tools for mapping DNA-protein interactions in single cells; and now that we have such a tool there is enormous excitement\u2014it’s really a foundational technological advance,” said study co-senior author Dr. Dan Landau, the Bibliowicz Family Professor of Medicine and a member of the\u00a0Sandra and Edward Meyer Cancer Center\u00a0and the Englander Institute for Precision Medicine\u00a0at Weill Cornell. Dr. Landau is also a core faculty member of the New York Genome Center.<\/p>\n

The study’s other co-senior author is Dr. Ivan Raimondi, senior molecular biologist and research innovation director in the Landau Lab. Wei-Yu Chi, a doctoral candidate in the Weill Cornell Graduate School of Medical Sciences and Dr. Sang-Ho Yoon, a postdoctoral associate in medicine in the Landau lab, are the co-first authors on the paper.<\/p>\n

Multi-omics refers to combined analyses of different layers of information within cells, including DNA sequences (genomes), gene activity patterns (transcriptomes), and protein populations…<\/p>\n

Source<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Novel technology maps single-cell DNA-protein interactions https:\/\/www.news-medical.net\/news\/20260604\/Novel-technology-maps-single-cell-DNA-protein-interactions.aspx Publish Date: 2026-06-04 15:52:00 Source Domain: www.news-medical.net A…<\/p>\n","protected":false},"author":1,"featured_media":264352,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/www.news-medical.net\/image-handler\/picture\/2014\/7\/Protein-620x480.jpg","fifu_image_alt":"","footnotes":""},"categories":[8],"tags":[101,62,119],"class_list":["post-264351","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-technology","tag-health","tag-innovation","tag-medical"],"_links":{"self":[{"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts\/264351"}],"collection":[{"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/comments?post=264351"}],"version-history":[{"count":1,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts\/264351\/revisions"}],"predecessor-version":[{"id":264353,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts\/264351\/revisions\/264353"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/media\/264352"}],"wp:attachment":[{"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/media?parent=264351"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/categories?post=264351"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/tags?post=264351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}