{"id":231955,"date":"2026-04-06T19:31:00","date_gmt":"2026-04-06T23:31:00","guid":{"rendered":"https:\/\/news-you-need.com\/index.php\/2026\/04\/06\/ai-finds-drug-safety-signals-in-clinical-notes\/"},"modified":"2026-04-06T19:45:12","modified_gmt":"2026-04-06T23:45:12","slug":"ai-finds-drug-safety-signals-in-clinical-notes","status":"publish","type":"post","link":"https:\/\/news-you-need.com\/index.php\/2026\/04\/06\/ai-finds-drug-safety-signals-in-clinical-notes\/","title":{"rendered":"AI finds drug safety signals in clinical notes"},"content":{"rendered":"<p><a href=\"https:\/\/news.vumc.org\/2026\/04\/06\/ai-finds-drug-safety-signals-in-clinical-notes\/\">AI finds drug safety signals in clinical notes<\/a><\/p>\n<p><a href=\"https:\/\/news.vumc.org\/2026\/04\/06\/ai-finds-drug-safety-signals-in-clinical-notes\/\">https:\/\/news.vumc.org\/2026\/04\/06\/ai-finds-drug-safety-signals-in-clinical-notes\/<\/a><\/p>\n<p>Publish Date: <a href=\"publish_date]\">2026-04-06 19:31:00<\/a><\/p>\n<p>Source Domain: <a href=\"news.vumc.org\">news.vumc.org<\/a><\/p>\n<p>Cosmin Bejan, PhD<\/p>\n<p>Drug safety signals often lurk in clinical notes and other text in electronic health records (EHR). Finding them requires costly manual chart abstraction or natural language processing with software tuned to a specific drug as documented at a specific center. This is the case with immune checkpoint inhibitors (ICIs), a type of cancer drug which first came to market in 2011, posing various immune-related adverse events, or irAEs, affecting the colon, liver, lungs, heart, nervous system, skin, and endocrine system.<\/p>\n<p>Large language models (LLMs), an increasingly inescapable form of artificial intelligence (AI), have come under study as a solution for speeding identification of drug safety signals buried in text. A multi-center study reported April 6 in eBioMedicine tests LLMs for detecting irAEs using models from Open AI, headquartered in San Francisco.\u00a0\u00a0<\/p>\n<p>The investigators use so-called zero-shot learning, where an LLM is given a single detailed prompt with no examples. The prompt developed by the team \u2014 \u201cYou are a clinical expert in identifying immune-related adverse events caused by immune checkpoint inhibitors \u2026\u201d \u2014 includes a list of six ICIs and dozens of their irAEs. The prompt is applied to randomly selected clinical notes of patients exposed to ICIs from Vanderbilt Health (100 patients) and the University of California at San Francisco (70 patients), and notes from seven ICI trials sponsored by Roche (272 patients), a pharmaceutical company based in Basel, Switzerland.\u00a0\u00a0<\/p>\n<p>\u201cManual patient chart abstraction for monitoring the safety and efficacy of drugs already at market requires tremendous resources and puts a drag on the pace of discovery in precision medicine. And that\u2019s especially true with immune checkpoint inhibitors, where the adverse events are so varied. If zero-shot learning with LLMs could help with these notes, it could significantly reduce time and costs for all concerned,\u201d said the report\u2019s&#8230;<\/p>\n<p><a href=\"https:\/\/news.vumc.org\/2026\/04\/06\/ai-finds-drug-safety-signals-in-clinical-notes\/\">Source<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>AI finds drug safety signals in clinical notes https:\/\/news.vumc.org\/2026\/04\/06\/ai-finds-drug-safety-signals-in-clinical-notes\/ Publish Date: 2026-04-06 19:31:00 Source Domain:&#8230;<\/p>\n","protected":false},"author":1,"featured_media":231956,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/vumc-reporter.s3.amazonaws.com\/uploads\/iStock-1137680279.jpg","fifu_image_alt":"","footnotes":""},"categories":[14],"tags":[17],"class_list":["post-231955","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artificial-intelligence","tag-llm"],"_links":{"self":[{"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts\/231955"}],"collection":[{"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/comments?post=231955"}],"version-history":[{"count":1,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts\/231955\/revisions"}],"predecessor-version":[{"id":231957,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts\/231955\/revisions\/231957"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/media\/231956"}],"wp:attachment":[{"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/media?parent=231955"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/categories?post=231955"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/tags?post=231955"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}