{"id":225725,"date":"2026-03-20T12:03:00","date_gmt":"2026-03-20T16:03:00","guid":{"rendered":"https:\/\/news-you-need.com\/index.php\/2026\/03\/20\/dicer-mechanism-to-control-rna-cleavage-precision\/"},"modified":"2026-03-20T12:05:09","modified_gmt":"2026-03-20T16:05:09","slug":"dicer-mechanism-to-control-rna-cleavage-precision","status":"publish","type":"post","link":"https:\/\/news-you-need.com\/index.php\/2026\/03\/20\/dicer-mechanism-to-control-rna-cleavage-precision\/","title":{"rendered":"DICER Mechanism To Control RNA Cleavage Precision"},"content":{"rendered":"<p><a href=\"https:\/\/www.technologynetworks.com\/tn\/news\/how-cells-edit-genetic-messages-with-accuracy-410888\">DICER Mechanism To Control RNA Cleavage Precision<\/a><\/p>\n<p><a href=\"https:\/\/www.technologynetworks.com\/tn\/news\/how-cells-edit-genetic-messages-with-accuracy-410888\">https:\/\/www.technologynetworks.com\/tn\/news\/how-cells-edit-genetic-messages-with-accuracy-410888<\/a><\/p>\n<p>Publish Date: <a href=\"publish_date]\">2026-03-20 12:03:00<\/a><\/p>\n<p>Source Domain: <a href=\"www.technologynetworks.com\">www.technologynetworks.com<\/a><\/p>\n<p dir=\"ltr\"><span>A research team from The Hong Kong University of Science and Technology (HKUST) has made a breakthrough discovery in understanding the molecular machinery of RNA silencing. The team uncovered how the human enzyme DICER achieves highly precise processing of microRNAs (miRNAs), advancing gene regulation research and offering new insights into the mechanisms underlying cancer, immune disorders, and genetic diseases.\u00a0<\/span><\/p>\n<p dir=\"ltr\"><span>This study, led by <\/span><span>Prof. Tuan Anh NGUYEN, Associate Professor in the Division of Life Science at HKUST<\/span><span> and jointly conducted by his <\/span><span>PhD students Minh Khoa NGO<\/span><span> and <\/span><span>Cong Truc LE<\/span><span>, has been published in the prestigious journal <\/span><span>Nature<\/span><span> under the title &#8220;<\/span><span>DICER cleavage fidelity is governed by 5\u2032-end binding pockets<\/span><span>.<\/span><span>&#8220;<\/span><\/p>\n<p dir=\"ltr\"><span>The message of human life is encoded in our genomic DNA through transcription of messenger RNAs which carries and executes the genetic instructions. RNA molecules, typically single-stranded and composed of ribonucleotides (A, U, G, and C), play essential cellular roles ranging from protein synthesis and gene regulation to serving as genetic material in certain viruses. Within this RNA-based regulatory landscape, the enzyme DICER functions as a highly precise &#8220;molecular scissors.&#8221; It cleaves double-stranded RNA precursors into short regulatory RNAs that are subsequently incorporated into the RNA-induced silencing complex (RISC), enabling the cell to identify and suppress incorrect or unnecessary genetic messages-much like marking and deleting errors in a text.\u00a0<\/span><\/p>\n<p dir=\"ltr\"><span>For years, researchers have sought to understand how DICER achieves its extraordinary cleavage accuracy. Using state-of-the-art biochemical and structural biology techniques and high-resolution cryoelectron microscopy (cryo-EM), the HKUST research team visualized DICER\u2013RNA interactions at an atomic level. The study&#8217;s first author Minh Khoa Ngo explained, &#8220;CryoEM allowed us to observe how RNA substrates engage with DICER at an atomic detail. These structural snapshots vividly&#8230;<\/span><\/p>\n<p><a href=\"https:\/\/www.technologynetworks.com\/tn\/news\/how-cells-edit-genetic-messages-with-accuracy-410888\">Source<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>DICER Mechanism To Control RNA Cleavage Precision https:\/\/www.technologynetworks.com\/tn\/news\/how-cells-edit-genetic-messages-with-accuracy-410888 Publish Date: 2026-03-20 12:03:00 Source Domain: www.technologynetworks.com&#8230;<\/p>\n","protected":false},"author":1,"featured_media":225726,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/assets.technologynetworks.com\/production\/dynamic\/images\/content\/410888\/yellow-cells-pixabay-640x360.jpg?cb=20260320","fifu_image_alt":"","footnotes":""},"categories":[8],"tags":[],"class_list":["post-225725","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-technology"],"_links":{"self":[{"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts\/225725"}],"collection":[{"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/comments?post=225725"}],"version-history":[{"count":1,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts\/225725\/revisions"}],"predecessor-version":[{"id":225727,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts\/225725\/revisions\/225727"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/media\/225726"}],"wp:attachment":[{"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/media?parent=225725"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/categories?post=225725"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/tags?post=225725"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}