{"id":221886,"date":"2026-03-10T06:02:00","date_gmt":"2026-03-10T10:02:00","guid":{"rendered":"https:\/\/news-you-need.com\/index.php\/2026\/03\/10\/a-novel-ihc-technology-for-tissue-cross-reactivity-screening-of-humanized-antibodies-in-human-tissue\/"},"modified":"2026-03-10T06:20:09","modified_gmt":"2026-03-10T10:20:09","slug":"a-novel-ihc-technology-for-tissue-cross-reactivity-screening-of-humanized-antibodies-in-human-tissue","status":"publish","type":"post","link":"https:\/\/news-you-need.com\/index.php\/2026\/03\/10\/a-novel-ihc-technology-for-tissue-cross-reactivity-screening-of-humanized-antibodies-in-human-tissue\/","title":{"rendered":"A novel IHC technology for tissue cross reactivity screening of humanized antibodies in human tissue"},"content":{"rendered":"<p><a href=\"https:\/\/www.selectscience.net\/resource\/a-novel-ihc-technology-for-tissue-cross-reactivity-screening-of-humanized-antibodies-in-human-tissue\">A novel IHC technology for tissue cross reactivity screening of humanized antibodies in human tissue<\/a><\/p>\n<p><a href=\"https:\/\/www.selectscience.net\/resource\/a-novel-ihc-technology-for-tissue-cross-reactivity-screening-of-humanized-antibodies-in-human-tissue\">https:\/\/www.selectscience.net\/resource\/a-novel-ihc-technology-for-tissue-cross-reactivity-screening-of-humanized-antibodies-in-human-tissue<\/a><\/p>\n<p>Publish Date: <a href=\"publish_date]\">2026-03-10 06:02:00<\/a><\/p>\n<p>Source Domain: <a href=\"www.selectscience.net\">www.selectscience.net<\/a><\/p>\n<p>This scientific poster introduces Vector Human-on-Human Detection, a novel immunohistochemistry technology designed for tissue cross-reactivity screening of humanized therapeutic antibodies in human tissues. The method overcomes challenges caused by endogenous human immunoglobulins that typically generate high background signals in standard IHC. Using a proprietary quenching reagent and HRP-based detection, the approach enables sensitive and specific detection of therapeutic antibodies in frozen and FFPE tissues without requiring antibody modification. The technology demonstrates strong signal-to-noise ratios and reliable detection across multiple therapeutic antibodies, supporting improved safety assessment during preclinical antibody development.<\/p>\n<p><a href=\"https:\/\/www.selectscience.net\/resource\/a-novel-ihc-technology-for-tissue-cross-reactivity-screening-of-humanized-antibodies-in-human-tissue\">Source<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A novel IHC technology for tissue cross reactivity screening of humanized antibodies in human tissue&#8230;<\/p>\n","protected":false},"author":1,"featured_media":221887,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"fifu_image_url":"https:\/\/cdn.sanity.io\/images\/f5b6mtfn\/selectscience-prod\/50e4bc19528c4f36a7e96a372ef4e43e69051050-856x632.png?rect=0,92,856,449&w=1200&h=630","fifu_image_alt":"","footnotes":""},"categories":[8],"tags":[],"class_list":["post-221886","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-technology"],"_links":{"self":[{"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts\/221886"}],"collection":[{"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/comments?post=221886"}],"version-history":[{"count":1,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts\/221886\/revisions"}],"predecessor-version":[{"id":221888,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/posts\/221886\/revisions\/221888"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/media\/221887"}],"wp:attachment":[{"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/media?parent=221886"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/categories?post=221886"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news-you-need.com\/index.php\/wp-json\/wp\/v2\/tags?post=221886"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}