Generalist biological artificial intelligence in modeling the language of life

Generalist biological artificial intelligence in modeling the language of life

Generalist biological artificial intelligence in modeling the language of life

https://www.nature.com/articles/s41587-026-03064-w

Publish Date: 2026-03-20 06:56:00

Source Domain: www.nature.com

  • Crick, F. Central dogma of molecular biology. Nature 227, 561–563 (1970).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Vaswani, A. et al. Attention is all you need. Adv. Neural Inf. Process. Syst. 30 (2017).

  • Naveed, H. et al. A comprehensive overview of large language models. ACM Trans. Intell. Syst. Technol. 16, 106 (2025).

    Article 

    Google Scholar 

  • Scarselli, F., Gori, M., Tsoi, A. C., Hagenbuchner, M. & Monfardini, G. The graph neural network model. IEEE Trans. Neural Netw. 20, 61–80 (2008).

    Article 
    PubMed 

    Google Scholar 

  • Ho, J., Jain, A. & Abbeel, P. Denoising diffusion probabilistic models. Adv. Neural Inf. Process. Syst. 33, 6840–6851 (2020).

    Google Scholar 

  • Wang, H. et al. Scientific discovery in the age of artificial intelligence. Nature 620, 47–60 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Jumper, J. et al. Highly accurate protein structure prediction with AlphaFold. Nature 596, 583–589 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Abramson, J. et al. Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature 630, 493–500 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jiang, K. et al. Rapid in silico directed evolution by a protein language model with EVOLVEpro. Science 387, eadr6006 (2025).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Brixi, G., Durrant, M.G., Ku, J. et al. Genome modelling and design across all domains of life with Evo 2. Nature https://doi.org/10.1038/s41586-026-10176-5 (2026).

  • Nguyen, E. et al. Sequence modeling and design from molecular to genome scale with Evo. Science 386, eado9336 (2024).

    Article 

  • Source